The cooling coils the air comes into contact with appear to need UV-C lights on them in humid climates. That's the biggest thing. If the ducts have never been cleaned, then getting that done goes without saying. But those coils need to be cleaned, disinfected, and then UV-C light(s) installed to prevent mold & bacteria build-up in the future on them. That appears to be chiefly responsible for the dirty laundry and/or sour milk smell coming from forced-air AC systems in humid regions.
This is where i found where the major problem was for the dust problem in my home. I took down the sheet metal that was 16" wide down by taking the screws out that keep it attached and when i took it down i, could not beleive the amountbof dust that was up there, inhad to put on breathing nasks to actually scoop out all the cust with my hads and then i used my shop vac then bleached everything, i would say that i filled up a 5 gallon maybe more not counting all the dust that was attached to the side of the beams that was all wood , because the contractor did not actually build a 16" wide return all out of metal , butvinstead used the sheet metal plate as a short cut to make a suare box using my beams in my basement to make a suare box. I was told contractors do that often and i feel that should be outlawed because it caused my sinus and allery problems,nwhich almost caused me to die. so everyone should make sure their ductwork was made properly. Yes seal it . Cover all openings. So it was not the contractors fault that my vents still had dust, in them, he was afraid tomgetvon top of my pool table to try to get iside the short cut ductwork with the 16" wide sheet metal. To everyone, make sure you clean your vent system. And make sure you could see it visually like i did , neither i or the contractor had no clue the problem was right above my pool table because of the make shift ductwork. The contactor shoul have made a squrae duct like the rest instead of using my beams as a short cut. That could be whyba lot of people start to have major allergy problems and maybe even ashma.so coverall holes to prevent dust to be taken in and all bugs etc. then make sure you clean your ductwork as you see reasonable, they say every 5 years , but i say evry 2 to 3 years, but you can do it yoursely.. You need a good air hose and suction vacum like a shop vac, do a little research. I invented something a while back like 18 to 20 years ago , and now it is on the market to help homeowners such as ourselves with this dust problem. I cannont say anymore because i have to make sure that it was not my research and idea that solved my problem and for all the others that are using what i invented ..there was nothing on the patent search that i hired an invention company to do, back then. Once yor vents are cleaned properly younwill be very happybif you are an allery sufferer. Stop the children for throwing things into the ductwork and sweeping things into the ductwork, keeping your vent system is clean once youbclean it right the first time, just maintain it , you dhould keepmthe hvac system clean such as coils etc it truly helps,people vome into my condo and they cannont beleive how cold it igets and how my system works so well. it is because i have my whole duct system sealed outsid with the duct sealant and my coils i vleaned my self and take the time that the furnase fan is cleaned because that could have a lot of major dust attached to it, mine had a lot of caked on dust it was like hard dirt. Yxounwill save on allergy bills nasal sprays, i wish I could say more because incould say something to really keep your whole duct system clean for years once you do a first good cleaning of intake and return vents. until i email one of the major companies to see where they got my idea from. Intrulybhope it was not from the invention company i hired years ago who did the patent search for my idea. I becam
I to had an odd layer of white'ish dust building up especially during seasonal periods when the HVAC ran a a lot. I carefully swept up the fine dust into a small pile and had it analyzed. Turns out it was very fine fiberglass powder dust. It turns out it is the insulation form the attic! (My attic has blown in insulation). Turns out if you (I) had small gaps around my HVAC registers in the ceiling whee the airs blows into the room. What occurred in my case was that the exiting air at that seam creates a vacuum effect at the grate vent cover and draws and then blows fine insulation dust from the attic into the house. Removing each register grate and sealing each tin outlet gap with calking between the dry wall ceiling and tin fixed the issue. A couple were so bad with bowed gaps I had to screw down the bowed tin to the attaching stud better. Checking the very same glass top desk that catches and shows any dust accumulation now shows only very small amounts of normal house dust build up over several weeks. A big, big improvement. You might have a look by simply removing a couple vent covers yourself.
You may consider having your air ducts cleaned simply because it seems logical that air ducts will get dirty over time and should be occasionally cleaned. Provided that the cleaning is done properly, no evidence suggests that such cleaning would be detrimental. EPA does not recommend that the air ducts be cleaned routinely, but only as needed. EPA does, however, recommend that if you have a fuel burning furnace, stove or fireplace, they be inspected for proper functioning and serviced before each heating season to protect against carbon monoxide poisoning.