The cooling coils the air comes into contact with appear to need UV-C lights on them in humid climates. That's the biggest thing. If the ducts have never been cleaned, then getting that done goes without saying. But those coils need to be cleaned, disinfected, and then UV-C light(s) installed to prevent mold & bacteria build-up in the future on them. That appears to be chiefly responsible for the dirty laundry and/or sour milk smell coming from forced-air AC systems in humid regions.
Yes everyone should get all their ductwork cleaned, because it does help, incame down with major allergies and had serval operations on my sinues because of this problem of air quality and dust, plus i almost died from one of the operations, i was suffering so much. Yes you can seal your duct system by buyind duct seal t instead of tape to tape all the corners of the vent system, tape wears out and gets brittle, the sealant you can buy at home depot, and you just brush it all over the connections of your ductwork, it comes in a container and it is like a thick paste and dries making a good seal for your ductwork.
I live in a 1950's ranch house in the South. The prior owners were smokers. Based on recommendations from one of the local conservation organizations, I decided to have a home energy audit done. As part of their findings, they recommended additional insulation in the attic and duct cleaning and sealing. This turned out to be a very problematic process. In terms of the ducts, it was necessary to remove the metal grates. However, these grates had been painted over many times and shoe molding covered the bottom of the grates. The vendor was not able to remove the grates without damaging them in the process. Because these grates dated back to the 1950's, it was difficult to find appropriate replacements. The ones I finally discovered were correct except they were 1/4" wider. This meant that the shoe molding had to be carved out. The duct cleaner could not provide any assistance with this problem. It took me a month of long evenings replacing the vent covers myself, carefully chiseling out the shoe molding and repainting. In terms of the extra installation in the attic, the same vendor used blow in insulation. Unfortunately, they did not recognize that the 13 floodlights whose mounting extended into the attic were not designed to be buried under insulation. The problem manifested itself in terms of expensive flood light bulbs failing continually. So, I had to have all of the light housings replaced. Yet another unexpected expense. Despite the expense, pain and suffering, I cannot report any improvement in my heating costs or the "quality" of the air. To be fair, I do not have any allergies and did not undertake this for air quality improvements but rather heating efficiency improvements.
Most people are now aware that indoor air pollution is an issue of growing concern and increased visibility. Many companies are marketing products and services intended to improve the quality of your indoor air. You have probably seen an advertisement, received a coupon in the mail, or been approached directly by a company offering to clean your air ducts as a means of improving your home's indoor air quality. These services typically — but not always — range in cost from $450 to $1,000 per heating and cooling system, depending on: