Despite such anecdotal experiences, there's no scientific evidence that regular residential air duct cleaning improves air quality, according to a 1997 brochure published by the Environmental Protection Agency. Laureen Burton, senior scientist in the EPA Indoor Environments Division, says that while the document is nearly two decades old, the science hasn't changed and the agency stands by its recommendations.
Some of the research I have done suggests to have your ducts cleaned when you first purchase a new home to remove drywall dust. Maintain your system well and you shouldn't have to do it again until you want to sell. Those are the two times cleaning was suggested. So for peace of mind maybe it is a good idea to do it even if you buy a used home and then maybe every 5-10 years.
When these aren't properly maintained and sanitized, they can build up dust, pollen, and even mold. This means when the air conditioner or heater turns on, the spores are released into the air for you to inhale. While some are less harmful, people who have allergies or sensitivity to certain spores will react negatively. Plus, mold is dangerous for anyone to ingest and should be avoided by regular maintenance.
Duct cleaning has never been shown to actually prevent health problems. Neither do studies conclusively demonstrate that particle (e.g., dust) levels in homes increase because of dirty air ducts. This is because much of the dirt in air ducts adheres to duct surfaces and does not necessarily enter the living space. It is important to keep in mind that dirty air ducts are only one of many possible sources of particles that are present in homes. Pollutants that enter the home both from outdoors and indoor activities such as cooking, cleaning, smoking, or just moving around can cause greater exposure to contaminants than dirty air ducts. Moreover, there is no evidence that a light amount of household dust or other particulate matter in air ducts poses any risk to your health.