One of the best ways to know if your ducts or vents need to be cleaned is to just check them. Your eyes will be able to check for indications of mold, dust or pollen buildup. You might also be able to smell the presence of mold, which would be a clear indicator. Ductwork will have some buildup of dust, since the return registrars pull air back in. However, this doesn't mean your ducts have too much debris, and you can easily clean them with a duster or vacuum.
On the other hand, if family members are experiencing unusual or unexplained symptoms or illnesses that you think might be related to your home environment, you should discuss the situation with your doctor. EPA has published the following publications for guidance on identifying possible indoor air quality problems and ways to prevent or fix them.
I just had my blower module replaced because my AC coil was frozen over. The underside of my coils had a thick mat of dust because I had never had it cleaned. I cleaned it myself by using a soft brush attachement on a shop vac. The inside of the blower appears to have a white/green growth, and I am sure the ductwork of my 30 year old house can’t be in good condition.
I know it has to have a new concentric venting system installed, I believe it needs new plenums ( mine are rusty but both of these require extra work , so someHVAC persons are saying I do not need either!! RED FLAG THERE. Also, it will need a new drain using PVCP ?? Piping run maybe two, depending on where my evep coil drain is conected (here in TN they use to run them in with the septic lines, now they cannot be run through that way), Lastly I am not where or what these things do beides hold water but I was told It needs a filter rack and new filter base safety pan. THATSSS it that is all I know about this stuff aside from the fact that nothing up there is to code thus far LOL. !!
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.