The cooling coils the air comes into contact with appear to need UV-C lights on them in humid climates. That's the biggest thing. If the ducts have never been cleaned, then getting that done goes without saying. But those coils need to be cleaned, disinfected, and then UV-C light(s) installed to prevent mold & bacteria build-up in the future on them. That appears to be chiefly responsible for the dirty laundry and/or sour milk smell coming from forced-air AC systems in humid regions.
Ok what you said is true but in most cases ducts are in a duct flex format, and knowing that the dust in people's flex duct is just surface dust, any real debris that are in the duct itself will result in very little to no air flow which will keep your unit from performing properly, but if it is true allergy reasons then replacing your duct system is better for overall better air quality, plus if you do pay attention to the warranty on flexible duct is that it only has a 10 year warranty and typically only lasts for 20 years so do your research before having a duct cleaning, and to add one more thing if your duct work is completely metal and you can't see visible insulation then your duct on the inside has insulation inside of it, if you replace that with duct work that is clean metal on the inside and wrapped with insulation on the outside then it will further reduce the air bourne fiberglass and dust.

I’m a heating and air conditioning contractor. I’ve been in the trade for over 15 years. I’ve witnessed numerous duct cleaning projects and talked with many duct cleaners. Duct cleaning as it’s usually promoted is a fraud. Most duct cleaners claim to deliver cleaner air. They deliver exactly the opposite. The studies on duct cleaning prove it, including a May 1998 study sponsored by NADCA and the EPA! The stories are compelling, but they can come up with stories that “prove” anything they want. Internet searches are dominated by results from those who are paid to tell you that duct cleaning is worthwhile. Search a little more and you’ll find the truth.

Pay particular attention to cooling coils, which are designed to remove water from the air and can be a major source of moisture contamination of the system that can lead to mold growth. Make sure the condensate pan drains properly. The presence of substantial standing water and/or debris indicates a problem requiring immediate attention. Check any insulation near cooling coils for wet spots.
Internal insulation provides better acoustical (noise) control. Flexible duct is very low cost. These products are engineered specifically for use in ducts or as ducts themselves, and are tested in accordance with standards established by Underwriters Laboratories (UL), the American Society for Testing and Materials (ASTM), and the National Fire Protection Association (NFPA). Many insulated duct systems have operated for years without supporting significant mold growth. Keeping them reasonably clean and dry is generally adequate. However, there is substantial debate about whether porous insulation materials (e.g., fiber glass) are more prone to microbial contamination than bare sheet metal ducts. If enough dirt and moisture are permitted to enter the duct system, there may be no significant difference in the rate or extent of microbial growth in internally lined or bare sheet metal ducts. However, treatment of mold contamination on bare sheet metal is much easier. Cleaning and treatment with an EPA-registered biocide are possible. Once fiberglass duct liner is contaminated with mold, cleaning is not sufficient to prevent re-growth and there are no EPA-registered biocides for the treatment of porous duct materials. EPA, NADCA and NAIMA all recommend the replacement of wet or moldy fiber glass duct material.

Equipment used to clean ducts varies widely. The cheaper the equipment used the more you are just wasting money. This is why it's typically not worth doing. In some situations it may be beneficial, but only after determining and investigating the duct system. This should be done by a licensed HVAC contractor and not a duct cleaner that typically do not hold and HVAC license. (Duct cleaners aren't required to be licensed in HVAC in many areas.)

In addition, the service provider may propose applying chemical biocides, designed to kill microbiological contaminants, to the inside of the duct work and to other system components. Some service providers may also suggest applying chemical treatments (sealants or other encapsulants) to encapsulate or cover the inside surfaces of the air ducts and equipment housings because they believe it will control mold growth or prevent the release of dirt particles or fibers from ducts. These practices have yet to be fully researched and you should be fully informed before deciding to permit the use of biocides or chemical treatments in your air ducts. They should only be applied, if at all, after the system has been properly cleaned of all visible dust or debris.
I live in a 1950's ranch house in the South. The prior owners were smokers. Based on recommendations from one of the local conservation organizations, I decided to have a home energy audit done. As part of their findings, they recommended additional insulation in the attic and duct cleaning and sealing. This turned out to be a very problematic process. In terms of the ducts, it was necessary to remove the metal grates. However, these grates had been painted over many times and shoe molding covered the bottom of the grates. The vendor was not able to remove the grates without damaging them in the process. Because these grates dated back to the 1950's, it was difficult to find appropriate replacements. The ones I finally discovered were correct except they were 1/4" wider. This meant that the shoe molding had to be carved out. The duct cleaner could not provide any assistance with this problem. It took me a month of long evenings replacing the vent covers myself, carefully chiseling out the shoe molding and repainting. In terms of the extra installation in the attic, the same vendor used blow in insulation. Unfortunately, they did not recognize that the 13 floodlights whose mounting extended into the attic were not designed to be buried under insulation. The problem manifested itself in terms of expensive flood light bulbs failing continually. So, I had to have all of the light housings replaced. Yet another unexpected expense. Despite the expense, pain and suffering, I cannot report any improvement in my heating costs or the "quality" of the air. To be fair, I do not have any allergies and did not undertake this for air quality improvements but rather heating efficiency improvements.
If not properly installed, maintained and operated, these components may become contaminated with particles of dust, pollen or other debris. If moisture is present, the potential for microbiological growth (e.g., mold) is increased and spores from such growth may be released into the home's living space. Some of these contaminants may cause allergic reactions or other symptoms in people if they are exposed to them. If you decide to have your heating and cooling system cleaned, it is important to make sure the service provider agrees to clean all components of the system and is qualified to do so. Failure to clean a component of a contaminated system can result in re-contamination of the entire system, thus negating any potential benefits. Methods of duct cleaning vary, although standards have been established by industry associations concerned with air duct cleaning. Typically, a service provider will use specialized tools to dislodge dirt and other debris in ducts, then vacuum them out with a high-powered vacuum cleaner.