Vacuum the ducts as much as possible. Consider renting a heavy duty vacuum for this purpose. The standard household vacuum isn't powerful enough to clean deep into the crevices of the ducts. Make sure that the vacuum you rent has a long hose to reach deep into the ducts. This is important, as there may be mold and mildew growing inside the air ducts [source: Repair Home]. If you want the ducts to be cleaned more thoroughly, consider hiring a professional to do the job.
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.