I am very interested by your post. We recently had a lead inspection on our property and one thing the lead inspector suggested was to get the air ducts cleaned out. We had our ducts cleaned last year after we under went a large renovation project (since we have a toddler in the house). This year we decided to go for lead compliance and had all our lead removed (we moved out for the work). Recently, my son had a false positive lead test, which prompted us to get a lead dust inspection around the house (including having the vents dust-wiped on the inside). The levels inside the ducts weren't crazy high (but more than would be acceptable for a floor). As it turned out my son's lead levels are very low (but not zero). Is it possible however that lead dust from the inside of a vent can come out? Would this be a scenario where you think air duct cleaning would be beneficial?
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.