If the system is sealed air-tight and a really good filtering system is in place then you should NEVER have to clean your ductwork. Most dust people see in their homes (on beds furniture etc....) is broken down insulation that is being blown into the home from the attic (venturi effect) where the duct bucket (box etc...) is not sealed at the sheetrock ceiling. On the return side, ANY leaks in the ductwork will pull hot attic air and dust into the system, clogging up everything.
I've been in business in Florida for 25 years and purchased a $12,000 duct cleaning system 4 years ago. In the last four years I've cleaned 5 duct systems charging around $400 each. Not a very good return on investment. What I have been doing most the time is I get a call by someone panicked because they called some low priced company to inspect their system and were told they have dangerous black mold. Then they call me to have a look. Most the time they don't have mold, ducts look very clean. However the coils are dirty and the inside of the air handler cabinet needs cleaning. Keep in mind not every system can handle supper high efficiency filters! These filters can block air flow quite a bit right out of the package. Many older systems can't handle pleated filters due to increased static pressure. "Back rooms with low air flow". I have taken many hours of classroom study on indoor air quality. Never got any certification because I don't want to pay another organization dues yearly. I think the problem with duct / system cleaning is most people are suckers for low priced scams that are rip- offs . People call me all the time and ask how much? When I tell them average $400 they hang up. I know I do the job correctly and honestly, and they are going to get racked over the coals by the scam artists by calling $79 whole house duct cleaning guys. People need to check internet, angies list and BBB reviews. But keep in mind even reviews need to be sifted through your rational person filter.
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.