Yes everyone should get all their ductwork cleaned, because it does help, incame down with major allergies and had serval operations on my sinues because of this problem of air quality and dust, plus i almost died from one of the operations, i was suffering so much. Yes you can seal your duct system by buyind duct seal t instead of tape to tape all the corners of the vent system, tape wears out and gets brittle, the sealant you can buy at home depot, and you just brush it all over the connections of your ductwork, it comes in a container and it is like a thick paste and dries making a good seal for your ductwork.
The amount of time it takes to clean a residential HVAC system depends on many variables such as the size of the home, the number of systems, the extent of the contamination and the number of HVAC cleaners performing the job. Ask at least two contractors to inspect your system and give you a time estimate for your particular system. This will give you a general idea of how long the job should take as well as an idea of how thoroughly the contractor plans to do the job.
You should be aware that although a substance may look like mold, a positive determination of whether it is mold or not can be made only by an expert and may require laboratory analysis for final confirmation. For about $50, some microbiology laboratories can tell you whether a sample sent to them on a clear strip of sticky household tape is mold or simply a substance that resembles it.