Preventing against air leakage is great, but the only way to keep dust and debris out of a duct system would be to completely seal off the return-air side of the system, which would render the system useless. Cold-air returns will always pull dust and other particles into the system. A high-MERV rated filter is definitely a good idea, but it does nothing to keep the return side of the system clean. Definitely agree though to use foil tape to seal seams, etc. Duct tape dries out over time and as it does can actually add more particles to the air.
Duct cleaning has never been shown to actually prevent health problems. Neither do studies conclusively demonstrate that particle (e.g., dust) levels in homes increase because of dirty air ducts. This is because much of the dirt in air ducts adheres to duct surfaces and does not necessarily enter the living space. It is important to keep in mind that dirty air ducts are only one of many possible sources of particles that are present in homes. Pollutants that enter the home both from outdoors and indoor activities such as cooking, cleaning, smoking, or just moving around can cause greater exposure to contaminants than dirty air ducts. Moreover, there is no evidence that a light amount of household dust or other particulate matter in air ducts poses any risk to your health.